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The small leucine-rich repeat proteins, fibromodulin and osteoadherin, have N-terminal extensions with a variable number of O-sulfated tyrosine residues.This modification combined with a number of aspartic and glutamic acid residues results in a highly negatively charged domain of less than 30 amino acids.

Bone matrix is a composite material that derives its strength from a compression-resistant mineral phase and a tension-resistant network of collagen fibers. Bone's mineral phase – calcium hydroxyapatite, Ca 10 (PO 4) 6 (OH) 2 – is subdivided into a mosaic of tiny microcrystallites, thereby creating a large surface area for ion exchange and limiting the spread of cracks. 2009-10-16 · The small leucine-rich repeat proteins, fibromodulin and osteoadherin, have N-terminal extensions with a variable number of O-sulfated tyrosine residues. This modification combined with a number of aspartic and glutamic acid residues results in a highly negatively charged domain of less than 30 amino acids. The LRR‐containing proteins include a family of nine small proteoglycans, forming three distinct subfamilies: class I contains biglycan/PG‐I and decorin/PG‐II; class II: lumican, fibromodulin, PRELP, keratocan, and osteoadherin; and class III: epiphycan/PG‐Lb and osteoglycin or osteoinductive factor.

The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone from a primary bovine osteoblast expression library. The entire Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. Country/Region selector. Utility Header Menu Right. 800-343-7475; Contact Us; Cart Osteoadherin (osteomodulin) is a 49,116-Da protein containing 11 leucine-rich repeats (LRRs), 3-4 tyrosine sulfate residues at the N-terminus, and six potential glycosylation sites for N-linked KS The distribution of these compounds was: the inner core express decorin, biglycan, lumican, fibromodulin, osteoadherin; the intermediate layer display immunoreactivity for osteoadherin; the outer core biglycan, decorin, lumican, fibromodulin and osteoadherin; and the capsule contains biglycan, decorin, fibromodulin, and lumican. (1998) Sommarin et al.

1998-07-03 · In order to further characterize osteoadherin, we have determined its primary structure. This reveals that osteoadherin belongs to the LRR family of connective tissue proteins. Osteoadherin is primarily expressed by mature osteoblasts, as shown in studies of its expression by in situ hybridization.

It promotes integrin (a vb 3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847).

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1999-12-30 Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucinerich proteoglycans (SLRP). LRR motifs consist of approximately 2030 amino acids (aa) with conserved leucine spacing, folded into a structure with one βsheet and one Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is encoded by the OMD gene. References Further reading. This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. This page was last edited on 12 A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine hydrochloride–containing EDTA. It was purified to homogeneity using a combination of ion-exchange chromatography, hydroxyapatite chromatography, and gel filtration.

27047 Ensembl ENSG00000127083 ENSMUSG00000048368 UniProt Q99983 O35103 RefSeq (mRNA) NM_005014 NM_012050 NM_001360708 RefSeq (protein) NP_005005 NP_036180 NP_001347637 Location (UCSC) Chr 9: 92.41 – 92.42 Mb Chr 13: 49.58 – 49.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847). The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone from a primary bovine osteoblast expression library.
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Synonyms: osteoadherin; SLRR2C; Keratan sulfate proteoglycan osteomodulin. The LRR‐containing proteins include a family of nine small proteoglycans, forming three distinct subfamilies: class I contains biglycan/PG‐I and decorin/PG‐II; class II: lumican, fibromodulin, PRELP, keratocan, and osteoadherin; and class III: epiphycan/PG‐Lb and osteoglycin or osteoinductive factor.

OMD (Osteomodulin) is a Protein Coding gene.
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A: Chelating agents such as EDTA, Heparin and Citrate can bind metal ions from the functional domain of Osteoadherin causing degradation of its protein structure. Osteoadherin may be denatured as a result and may compromise the assay's measurements.

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KS chains in fibromodulin and osteoadherin are relatively short (8–9 disaccharides) and are more highly sulfated than KS in cornea (Lauder et al., 1997). KS in fibromodulin lacks the clear domain structure of corneal KS, but like corneal KS it displays reduced Gal sulfation near the reducing terminus.

800-343-7475; Contact Us; Cart The small leucine-rich repeat proteins, fibromodulin and osteoadherin, have N-terminal extensions with a variable number of O-sulfated tyrosine residues.This modification combined with a number of aspartic and glutamic acid residues results in a highly negatively charged domain of less than 30 amino acids. For instance, conjugated polymers with a delocalized electronic structure are enabled by coupling with optoelectronic segments, imaging, diagnosis, and therapy (Zhu et al., 2012a). In addition, Wang et al. have reported about an organic/inorganic hybrid nanoparticle, which are magnetic IONPs modified with the fluorescent conjugated polyelectrolyte (BtPFN).

Browse information about OMD (ENSG00000127083) covering related drugs, protein structure, pathways, genetic associations, orthologs, RNA expression and cancer biomarkers. Synonyms: osteoadherin; SLRR2C; Keratan sulfate proteoglycan osteomodulin.

It promotes integrin (αvβ3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847). The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone from a primary bovine osteoblast expression library. The entire The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone from a primary bovine osteoblast expression library.